CAS No. 911637-19-9
Batch:
Purity:98.95
Chemical Structure
Check the
Gemigliptin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one | |
|---|---|---|
| CAS Number | 911637-19-9 | |
| Molecular Formula |
C18H19F8N5O2 |
|
| Molecular Weight (MW) | 489.36 | |
| SMILES | NC(CN1CC(F)(F)CCC1=O)CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F | |
| InChIKey | ZWPRRQZNBDYKLH-VIFPVBQESA-N |
Gemigliptin is a potent, selective dipeptidyl peptidase 4 (DPP-4) inhibitor with a Ki of 7.25 nM and exhibits at least 23,000-fold selectivity for DPP-4 over related enzymes including DPP-8, DPP-9, and fibroblast activation protein-α. Inhibition of DPP-4 prevents the enzymatic cleavage and degradation of active glucagon-like peptide-1 (GLP-1), which in turn enhances glucose-dependent insulin secretion and suppresses glucagon release, ultimately improving glucose tolerance and lowering blood glucose levels. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 12 mg/mL |
| Ethanol | 7 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.