CAS No. 95058-81-4

Batch: Purity:99.98
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Gemcitabine Chemical Structure
Chemical Structure
Check the Gemcitabine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
CAS Number 95058-81-4
Molecular Formula

C9H11F2N3O4
Molecular Weight (MW) 263.2
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F
InChIKey SDUQYLNIPVEERB-QPPQHZFASA-N

Ordering Information

Biological Activity

Gemcitabine is a deoxycytidine analogue and nucleic acid synthesis inhibitor that targets ribonucleotide reductase and DNA replication. Upon intracellular phosphorylation, gemcitabine incorporates into DNA to block chain elongation and inhibit cell proliferation. This incorporation disrupts DNA synthesis and repair pathways, resulting in cell cycle arrest and inducing potent p53-dependent apoptosis in cancer cells. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 53 mg/mL (201.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.