CAS No. 184475-55-6

Batch: Purity:99.94
Check CoA
Gefitinib hydrochloride Chemical Structure
Chemical Structure
Check the Gefitinib hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 184475-55-6
Molecular Formula

C22H24ClFN4O3.HCl
Molecular Weight (MW) 483.36
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl

Ordering Information

Biological Activity

Gefitinib hydrochloride is an orally active, potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. By competing with ATP for binding to the intracellular catalytic domain of EGFR, gefitinib selectively blocks receptor autophosphorylation and suppresses downstream MAPK and AKT/mTOR signaling pathways. This target inhibition effectively suppresses tumor cell proliferation, induces cell cycle arrest and apoptosis, and attenuates tumor growth in xenograft models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 4 mg/mL (8.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 1 mg/mL
Ethanol 1 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.