CAS No. 1453848-26-4
Batch:
Purity:99.73
Chemical Structure
Check the
Ravoxertinib (GDC-0994)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one | |
|---|---|---|
| CAS Number | 1453848-26-4 | |
| Molecular Formula |
C21H18ClFN6O2 |
|
| Molecular Weight (MW) | 439.85 | |
| SMILES | CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(C=C4)Cl)F | |
| InChIKey | RZUOCXOYPYGSKL-GOSISDBHSA-N |
Ravoxertinib (GDC-0994) is an orally bioavailable, highly selective inhibitor of ERK1 (IC50 of and ERK2 (IC50 of. By blocking ERK1/2 activity, the compound inhibits downstream phosphorylation within the MAPK/ERK pathway. Consequently, it suppresses tumor cell proliferation and induces apoptosis in MAPK pathway-dependent cancer cell lines and xenograft models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
87 mg/mL
(197.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Ravoxertinib (GDC-0994) Clinical Trials
- Ravoxertinib (GDC-0994) Solubility in DMSO
- Ravoxertinib (GDC-0994) Stock Solution
- Ravoxertinib (GDC-0994) Storage
- Ravoxertinib (GDC-0994) Stability
- Ravoxertinib (GDC-0994) Molecular Weight
- Ravoxertinib (GDC-0994) SMILES
- Ravoxertinib (GDC-0994) Chemical Structure (2D and 3D)
- Ravoxertinib (GDC-0994) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.