CAS No. 1448693-69-3

Batch: Purity:98.95
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GCN2-IN-1 Chemical Structure
Chemical Structure
Check the GCN2-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(1H-indazol-6-yl)-N-[1-(oxan-4-yl)pyrazol-4-yl]triazolo[4,5-d]pyrimidin-5-amine
CAS Number 1448693-69-3
Molecular Formula

C19H18N10O
Molecular Weight (MW) 402.41
InChIKey CFNFLNGJQOHNPR-UHFFFAOYSA-N

Ordering Information

Biological Activity

GCN2-IN-1 (A-92) is an active site inhibitor of general control nonderepressible 2 kinase (GCN2, IC50 <0.3 μM). By inhibiting GCN2 autophosphorylation, it blocks downstream integrated stress response signaling, leading to reduced phosphorylation of eIF2α and decreased expression of ATF4. In cell models, GCN2-IN-1 suppresses adaptive transcriptional programs under nutrient stress, inhibits HIV-1 integrase phosphorylation, and modulates retroviral integration efficiency.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.