CAS No. 1507930-57-5
Batch:
Purity:99.67
Chemical Structure
Check the
Gap19
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid | |
|---|---|---|
| CAS Number | 1507930-57-5 | |
| Molecular Formula |
C55H96N14O13 |
|
| Molecular Weight (MW) | 1161.44 | |
| SMILES | CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCCN)C(O)=O | |
| InChIKey | IEAKEKFIXUZWEH-PKMKMBMKSA-N |
Gap19 is a selective connexin 43 (Cx43) hemichannel blocker (IC50 6.5 μM when applied intracellularly) derived from nine amino acids of the Cx43 cytoplasmic loop. By specifically inhibiting Cx43 hemichannels without impairing Cx43 gap junctions, Gap19 suppresses excessive ATP release and calcium influx during cell stress. This blockade protects against cellular injury, reducing infarct size and dysfunction in ischemia-reperfusion models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(86.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.