CAS No. 357-70-0

Batch: Purity:99.97
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Galanthamine Chemical Structure
Chemical Structure
Check the Galanthamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
CAS Number 357-70-0
Molecular Formula

C17H21NO3
Molecular Weight (MW) 287.35
InChIKey ASUTZQLVASHGKV-JDFRZJQESA-N

Ordering Information

Biological Activity

Galanthamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase (AChE) inhibitor, exhibiting 50-fold selectivity against butyrylcholinesterase (BChE). By inhibiting AChE-mediated acetylcholine hydrolysis, galanthamine increases synaptic acetylcholine concentrations and modulates cholinergic neurotransmission. Additionally, it acts as an allosteric potentiating ligand at nicotinic acetylcholine receptors to enhance central nervous system cholinergic signaling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (139.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 20 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.