CAS No. 319492-82-5
Batch:
Purity:99.37
Chemical Structure
Check the
GAK inhibitor 49
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine | |
|---|---|---|
| CAS Number | 319492-82-5 | |
| Molecular Formula |
C20H22N2O5 |
|
| Molecular Weight (MW) | 370.4 | |
| SMILES | COC1=CC(=CC(=C1OC)OC)NC2=C3C=C(C(=CC3=NC=C2)OC)OC | |
| InChIKey | VYPGLYMWNDRFGZ-UHFFFAOYSA-N |
GAK inhibitor 49 functions as a potent, ATP-competitive, and highly selective inhibitor of cyclin G-associated kinase (GAK). By selectively inhibiting GAK kinase activity, the compound modulates clathrin-mediated endocytosis and intracellular membrane trafficking. Disruption of these GAK-dependent pathways regulates cell surface receptor recycling, impairs EGFR transport, and attenuates viral entry mechanisms across multiple biological systems.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.