CAS No. 56974-61-9
| IUPAC Name | ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid | |
|---|---|---|
| CAS Number | 56974-61-9 | |
| Molecular Formula |
C16H23N3O4.CH4O3S |
|
| Molecular Weight (MW) | 417.48 | |
| SMILES | CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N.CS(=O)(=O)O | |
| InChIKey | DNTNDFLIKUKKOC-UHFFFAOYSA-N |
Gabexate Mesylate is a synthetic serine protease inhibitor that targets proteases including trypsin, thrombin, and kallikrein. By inhibiting serine protease activity, Gabexate Mesylate modulates inflammatory signaling pathways, suppressing NF-kB activation and downstream pro-inflammatory cytokine expression such as TNF-α and IL-6. This inhibition attenuates inflammatory responses and endothelial cell injury associated with protease-mediated signaling networks.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(198.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | 12 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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