CAS No. 939681-36-4
Batch:
Purity:99.29
Chemical Structure
Check the
G5-7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]-4-oxopiperidine-1-carboxylate | |
|---|---|---|
| CAS Number | 939681-36-4 | |
| Molecular Formula |
C22H19F2NO3 |
|
| Molecular Weight (MW) | 383.39 | |
| SMILES | CCOC(=O)N1CC(=C/C2=CC=CC=C2F)/C(=O)C(/C1)=C\C3=CC=CC=C3F | |
| InChIKey | FPAYMMBGZTYNSI-WHYMJUELSA-N |
G5-7 is an orally active allosteric Janus kinase 2 (JAK2) inhibitor that selectively blocks JAK2-mediated phosphorylation and activation of EGFR (at Tyr and STAT3 by binding to JAK2. This inhibition attenuates downstream mTOR signaling, impairs tumor cell proliferation, and induces cell cycle arrest and apoptosis in glioblastoma cells while decreasing vascular endothelial growth factor secretion and endothelial cell migration. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(99.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.