CAS No. 1161002-05-6
Batch:
Purity:99.35
Chemical Structure
Check the
G15
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | |
|---|---|---|
| CAS Number | 1161002-05-6 | |
| Molecular Formula |
C19H16BrNO2 |
|
| Molecular Weight (MW) | 370.24 | |
| SMILES | C1C=CC2C1C(NC3=CC=CC=C23)C4=CC5=C(C=C4Br)OCO5 | |
| InChIKey | YOLTZIVRJAPVPH-MJLGCCKJSA-N |
G15 is a cell-permeable and selective G-protein coupled estrogen receptor (GPER/GPR30) antagonist with a binding affinity of approximately, showing no affinity for ERα or ERβ at concentrations up to. By blocking GPER, G15 inhibits downstream estrogen-stimulated signal transduction, including ERK phosphorylation and intracellular calcium mobilization. This inhibition suppresses estrogen-mediated cell proliferation and physiological cellular responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(199.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.