CAS No. 2369751-07-3
Batch:
Purity:99.29
Chemical Structure
Check the
G140
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone | |
|---|---|---|
| CAS Number | 2369751-07-3 | |
| Molecular Formula |
C17H16Cl2N4O2 |
|
| Molecular Weight (MW) | 379.24 | |
| SMILES | C[N]1C=CC(=N1)C2=C3C4=C(CCN(C4)C(=O)CO)[NH]C3=C(Cl)C(=C2)Cl | |
| InChIKey | NVPFAXHXXODQRO-UHFFFAOYSA-N |
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), demonstrating targeted inhibition against both human and mouse cGAS enzymes. By blocking cGAS catalytic activity, G140 prevents the synthesis of cyclic GMP-AMP (cGAMP) and suppresses downstream STING pathway activation. This inhibition leads to reduced type I interferon production and attenuated inflammatory signaling in cGAS-dependent cellular phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.