CAS No. 1448169-71-8

Batch: Purity:99.92
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Futibatinib (TAS-120) Chemical Structure
Chemical Structure
Check the Futibatinib (TAS-120) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one
CAS Number 1448169-71-8
Molecular Formula

C22H22N6O3
Molecular Weight (MW) 418.45
SMILES COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)C4CCN(C4)C(=O)C=C)OC
InChIKey KEIPNCCJPRMIAX-HNNXBMFYSA-N

Ordering Information

Biological Activity

Futibatinib (TAS-120) is an irreversible inhibitor of fibroblast growth factor receptors, targeting FGFR1, FGFR2 (IC50 1.4 nM), FGFR3, and FGFR4 (IC50 3.7 nM). By covalently binding to the ATP-binding pocket of FGFRs, it suppresses receptor autophosphorylation and downstream signaling pathways. Consequently, futibatinib inhibits cell proliferation and selectively induces cell death in cancer cell lines carrying FGFR genomic alterations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.