CAS No. 751-94-0

Batch: Purity:97
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Fusidate Sodium Chemical Structure
Chemical Structure
Check the Fusidate Sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate
CAS Number 751-94-0
Molecular Formula

C31H47O6.Na
Molecular Weight (MW) 538.69
SMILES CC1C2CCC3(C(C2(CCC1O)C)C(CC4C3(CC(C4=C(CCC=C(C)C)C(=O)[O-])OC(=O)C)C)O)C.[Na+]
InChIKey HJHVQCXHVMGZNC-JCJNLNMISA-M

Biological Activity

Fusidate Sodium is a bacteriostatic steroidal antibiotic that acts as an inhibitor of bacterial elongation factor G (EF-G). It binds to EF-G on the ribosome during translocation and prevents the dissociation of EF-G from the ribosome following GTP hydrolysis. This locks the EF-G-GDP-ribosome complex, stalling ribosomal translocation and suppressing bacterial protein synthesis. Consequently, this disrupts bacterial cell growth and proliferation across susceptible strains. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (185.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gao YG, et al. Science. 2009;326(5953):694-9.

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Note: Technical data last updated: Sep 1, 2026.