CAS No. 804-30-8

Batch: Purity:99.99
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Fursultiamine Chemical Structure
Chemical Structure
Check the Fursultiamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide
CAS Number 804-30-8
Molecular Formula

C17H26N4O3S2
Molecular Weight (MW) 398.54
SMILES CC1=NC=C(C(=N1)N)CN(C=O)C(=C(CCO)SSCC2CCCO2)C
InChIKey JTLXCMOFVBXEKD-FOWTUZBSSA-N

Ordering Information

Biological Activity

Fursultiamine is a lipophilic vitamin B1 derivative and precursor that targets thiamine-dependent enzymatic pathways. By increasing intracellular thiamine pyrophosphate levels, it modulates key metabolic enzymes, including pyruvate dehydrogenase and transketolase. This regulation influences cellular glucose metabolism, energy production, and pentose phosphate pathway flux, ultimately suppressing cell proliferation and modulating cellular metabolic phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40 mg/mL
Water 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.