CAS No. 116355-83-0
Chemical Structure
Check the
Fumonisin B1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid | |
|---|---|---|
| CAS Number | 116355-83-0 | |
| Molecular Formula |
C34H59NO15 |
|
| Molecular Weight (MW) | 721.83 | |
| InChIKey | UVBUBMSSQKOIBE-DSLOAKGESA-N |
Biological Activity
Fumonisin B1 is a mycotoxin and potent inhibitor of sphingosine N-acyltransferase (ceramide synthase, IC50 = 0.1 µM in rat liver microsomes). By blocking ceramide synthase, it disrupts the de novo synthesis of sphingolipids and reduces the conversion of sphingosine to ceramide in intact hepatocytes, leading to altered cellular sphingolipid metabolism and compromised downstream cell survival pathways. [1]
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Note: Technical data last updated: Sep 1, 2026.