CAS No. 1644060-37-6
Batch:
Purity:99.02
Chemical Structure
Check the
Fumarate hydratase-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1644060-37-6 | |
|---|---|---|
| Molecular Formula |
C27H30N2O4 |
|
| Molecular Weight (MW) | 446.54 |
Biological Activity
Fumarate hydratase-IN-1 is a cell-permeable small-molecule inhibitor of fumarate hydratase (FH). Pharmacological inhibition of FH alters tricarboxylic acid cycle metabolite homeostasis and triggers substantial cellular redox stress responses. Accumulation of fumarate promotes mitochondrial nucleic acid release into the cytosol, which drives downstream activation of type I interferon production and inflammatory immune signaling pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.