CAS No. 23110-15-8

Batch: Purity:97
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Fumagillin Chemical Structure
Chemical Structure
Check the Fumagillin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
CAS Number 23110-15-8
Molecular Formula

C26H34O7
Molecular Weight (MW) 458.54
SMILES CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
InChIKey NGGMYCMLYOUNGM-CSDLUJIJSA-N

Ordering Information

Biological Activity

Fumagillin is a selective and potent irreversible inhibitor of methionine aminopeptidase 2 (MetAP2). Covalent modification of MetAP2 by fumagillin blocks the removal of N-terminal methionine residues from nascent proteins, disrupting essential cellular processing pathways. Consequently, fumagillin selectively inhibits endothelial cell proliferation and tumor angiogenesis while exhibiting potent antiparasitic activity against microsporidial infections. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.