CAS No. 2641747-54-6
Batch:
Purity:97.26
Chemical Structure
Check the
Fulzerasib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-7,9-dimethyl-12-(4-methyl-2-propan-2-yl-3-pyridinyl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione | |
|---|---|---|
| CAS Number | 2641747-54-6 | |
| Molecular Formula |
C32H30ClFN6O4 |
|
| Molecular Weight (MW) | 617.07 | |
| InChIKey | BRWVQEWFJJFLIQ-MGBGTMOVSA-N |
Biological Activity
Fulzerasib is an irreversible covalent inhibitor targeting the KRAS G12C mutant protein. By binding to the inactive state of KRAS G12C, it disrupts downstream RAS signaling through the MAPK/ERK pathway and potently suppresses phosphorylation of ERK. This target inhibition leads to suppressed cell proliferation, induction of apoptosis, and robust preclinical antitumor activity across multiple KRAS G12C-mutant tumor models, including pancreatic, lung, and colorectal cancers. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(162.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.