CAS No. 180977-34-8

Batch: Purity:99.39
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FTI 277 HCl Chemical Structure
Chemical Structure
Check the FTI 277 HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;hydrochloride
CAS Number 180977-34-8
Molecular Formula

C22H30ClN3O3S2
Molecular Weight (MW) 484.07
SMILES COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl
InChIKey PIAFFJUUNXEDEW-PXPMWPIZSA-N

Ordering Information

Biological Activity

FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 500 pM) with 100-fold selectivity over GGTase I. By blocking FTase, FTI 277 HCl inhibits the farnesylation and membrane localization of Ras, thereby disrupting downstream Ras/MAPK signaling cascades. This inhibition suppresses oncogenic Ras-stimulated cell growth and promotes apoptotic cell death in cancer cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (198.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 96 mg/mL
Ethanol 96 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.