CAS No. 2225728-57-2
Batch:
Purity:99.83
Chemical Structure
Check the
FT895
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)pyrazin-2-yl]-3H-isoindole-4-carboxamide | |
|---|---|---|
| CAS Number | 2225728-57-2 | |
| Molecular Formula |
C16H15F3N4O2 |
|
| Molecular Weight (MW) | 352.31 | |
| SMILES | O=C(NO)C1=C(CN(C2=CN=C(C(F)(F)F)C=N2)C3(C)C)C3=CC=C1 | |
| InChIKey | XCLPBILTRRWOIL-UHFFFAOYSA-N |
Biological Activity
FT895 is a potent and selective inhibitor of histone deacetylase 11 (HDAC11) relative to other HDAC family enzymes. Targeted inhibition of HDAC11 disrupts its catalytic regulatory function in gene transcription, leading to altered chromatin structure and immune pathway signaling. This enzymatic inhibition increases downstream cellular production of key regulatory cytokines, including interleukin-10, thereby modulating inflammatory and immune cell phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.