CAS No. 1630808-89-7
Batch:
Purity:99.76
Chemical Structure
Check the
FT113
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [4-(6-fluoro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone | |
|---|---|---|
| CAS Number | 1630808-89-7 | |
| Molecular Formula |
C22H20FN3O4 |
|
| Molecular Weight (MW) | 409.41 | |
| SMILES | C1CC1(C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)C4=NC5=C(O4)C=C(C=C5)F)O | |
| InChIKey | DSTWHRGOCUOKDE-UHFFFAOYSA-N |
FT113 is a small-molecule inhibitor of fatty acid synthase (FASN). FASN serves as a central enzyme in de novo lipogenesis, converting acetyl-CoA and malonyl-CoA into long-chain fatty acids. Inhibition of FASN suppresses lipid biosynthesis, impairs membrane lipid raft formation, and induces cellular metabolic stress, resulting in down-regulation of oncogenic signaling pathways and inhibition of cell proliferation. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
28 mg/mL
(68.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.