CAS No. 26130-02-9
Batch:
Purity:99.95
Chemical Structure
Check the
Frentizole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea | |
|---|---|---|
| CAS Number | 26130-02-9 | |
| Molecular Formula |
C15H13N3O2S |
|
| Molecular Weight (MW) | 299.35 | |
| SMILES | COC1=CC2=C(C=C1)N=C(S2)NC(=O)NC3=CC=CC=C3 | |
| InChIKey | JHBWYQRKOUBPCA-UHFFFAOYSA-N |
Frentizole is a small-molecule inhibitor of the interaction between amyloid-beta peptide and amyloid-beta binding alcohol dehydrogenase (ABAD). By blocking ABAD-amyloid-beta complex formation, frentizole suppresses mitochondrial dysfunction, mitigates reactive oxygen species generation, and attenuates cellular toxicity. Consequently, frentizole preserves mitochondrial membrane potential and protects neuronal cells against amyloid-beta-induced cell death in Alzheimer's disease models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.