CAS No. 574-84-5
Batch:
Purity:99.88
Chemical Structure
Check the
Fraxetin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7,8-dihydroxy-6-methoxychromen-2-one | |
|---|---|---|
| CAS Number | 574-84-5 | |
| Molecular Formula |
C10H8O5 |
|
| Molecular Weight (MW) | 208.17 | |
| SMILES | COC1=C(C(=C2C(=C1)C=CC(=O)O2)O)O | |
| InChIKey | HAVWRBANWNTOJX-UHFFFAOYSA-N |
Fraxetin is a natural coumarin derivative with potent antioxidant activity. It alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, and attenuates CYP2E1 activity. Furthermore, fraxetin suppresses the production of inflammatory mediators, including TNF-α and IL-1β, by upregulating heme oxygenase-1 (HO-1) protein levels, thereby protecting hepatic cells against oxidative stress and inflammatory damage.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(201.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
42 mg/mL
(201.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.