CAS No. 1232030-35-1
| IUPAC Name | 6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 1232030-35-1 | |
| Molecular Formula |
C25H23Cl2FN6O |
|
| Molecular Weight (MW) | 513.39 | |
| SMILES | CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F | |
| InChIKey | DHKFOIHIUYFSOF-UHFFFAOYSA-N |
FRAX486 is a potent p21-activated kinase (PAK) inhibitor that targets group I PAKs, including PAK1, PAK2, and PAK3, as well as PAK4. By inhibiting PAK signaling downstream of small GTPases, FRAX486 modulates actin cytoskeleton dynamics and neuronal synaptic morphology. In preclinical animal models, pharmacological inhibition by FRAX486 rescues dendritic spine dysmorphology, reduces audiogenic seizure susceptibility, and ameliorates repetitive behavioral phenotypes.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(29.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
33 mg/mL
(64.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
22 mg/mL
(42.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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