CAS No. 1432908-05-8
Batch:
Purity:98.62
Chemical Structure
Check the
FRAX1036
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 1432908-05-8 | |
| Molecular Formula |
C28H32ClN7O |
|
| Molecular Weight (MW) | 518.05 | |
| SMILES | CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=NC(=CN=C4)C)Cl)NCCC5CCN(CC5)C | |
| InChIKey | RYCBSFIKWACFBY-UHFFFAOYSA-N |
FRAX1036 is a small-molecule inhibitor targeting p21-activated kinases PAK1 and PAK2. By inhibiting PAK family kinase activity, FRAX1036 blocks Rac/Cdc42-dependent signaling pathways, leading to the disruption of actin cytoskeletal dynamics, cell migration, and cell cycle progression in cancer models. These biological activities highlight its utility as a chemical tool for investigating PAK-mediated cellular functions and oncogenic signaling cascades. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 4-Methylpyridine | 21 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.