CAS No. 1335282-05-7
Batch:
Purity:99.85
Chemical Structure
Check the
FOT1（CN128）hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1335282-05-7 | |
|---|---|---|
| Molecular Formula |
C15H17NO3.ClH |
|
| Molecular Weight (MW) | 295.76 |
Biological Activity
FOT1 (CN128) hydrochloride is an orally active hydroxypyridinone iron chelator that targets labile intracellular and systemic iron pools. By sequestrating excess iron, it attenuates iron-mediated reactive oxygen species generation and inhibits the accumulation of toxic intermediates resulting from iron-dependent dopamine oxidation. Consequently, this compound suppresses oxidative stress, protects dopaminergic neurons in models of Parkinson’s disease, and mitigates systemic iron overload. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.