CAS No. 914295-16-2
Batch:
Purity:99.8
Chemical Structure
Check the
Fostamatinib disodium hexahydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate;hexahydrate | |
|---|---|---|
| CAS Number | 914295-16-2 | |
| Molecular Formula |
C23H36FN6Na2O15P |
|
| Molecular Weight (MW) | 732.51 | |
| SMILES | O.O.O.O.O.O.[Na+].[Na+].COC1=CC(=CC(=C1OC)OC)NC2=NC=C(F)C(=N2)NC3=NC4=C(OC(C)(C)C(=O)N4CO[P]([O-])([O-])=O)C=C3 | |
| InChIKey | ZQGJCHHKJNSPMS-UHFFFAOYSA-L |
Fostamatinib disodium hexahydrate is an orally bioavailable prodrug of R406, a selective spleen tyrosine kinase (Syk) inhibitor. Upon conversion to R406, it suppresses Syk-mediated signaling pathways downstream of Fc receptors and B-cell receptors. This inhibition blocks activation of downstream cascades, leading to reduced mast cell and basophil degranulation, impaired macrophage activation, and suppressed inflammatory cell recruitment. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(136.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Fostamatinib disodium hexahydrate Clinical Trials
- Fostamatinib disodium hexahydrate Solubility in DMSO
- Fostamatinib disodium hexahydrate Stock Solution
- Fostamatinib disodium hexahydrate Storage
- Fostamatinib disodium hexahydrate Stability
- Fostamatinib disodium hexahydrate Molecular Weight
- Fostamatinib disodium hexahydrate SMILES
- Fostamatinib disodium hexahydrate Chemical Structure (2D and 3D)
- Fostamatinib disodium hexahydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.