CAS No. 92134-98-0

Batch: Purity:99.94
Check CoA
Fosphenytoin (disodium) Chemical Structure
Chemical Structure
Check the Fosphenytoin (disodium) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 92134-98-0
Molecular Formula

C16H13N2Na2O6P
Molecular Weight (MW) 406.24
SMILES C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]

Ordering Information

Biological Activity

Fosphenytoin (disodium) is a water-soluble prodrug of the anticonvulsant agent phenytoin. Upon enzymatic hydrolysis by phosphatases, it converts into active phenytoin, which acts as a voltage-gated sodium channel blocker. By stabilizing the inactive state of voltage-gated sodium channels, it inhibits high-frequency sustained repetitive firing of action potentials in neurons and dampens excessive excitatory neurotransmission within central nervous system pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 81 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.