CAS No. 2925468-57-9
Batch:
Purity:95.44
Chemical Structure
Check the
FMC-376
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(3R)-3-[[7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-methylamino]pyrrolidin-1-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 2925468-57-9 | |
| Molecular Formula |
C35H33F3N6O2 |
|
| Molecular Weight (MW) | 626.67 | |
| InChIKey | MTGHJFNZUOUZEX-MELYXTHRSA-N |
FMC-376 is a selective and irreversible dual inhibitor targeting both the active ON and inactive OFF states of mutant KRAS G12C. By covalently binding to cysteine 12, it disrupts KRAS G12C conformation and blocks downstream RAS/MAPK signaling pathways. This complete inhibition suppresses tumor cell proliferation and demonstrates potent in vivo anti-tumor efficacy across KRAS G12C-driven cancer models. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(159.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.