CAS No. 329932-55-0
Batch:
Purity:99.00
Chemical Structure
Check the
FM19G11
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [2-(4-methylphenyl)-2-oxoethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate | |
|---|---|---|
| CAS Number | 329932-55-0 | |
| Molecular Formula |
C23H17N3O8 |
|
| Molecular Weight (MW) | 463.40 | |
| InChIKey | XVUOIWIIQVGWAJ-UHFFFAOYSA-N |
FM19G11 is a small-molecule hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor that suppresses hypoxia-induced luciferase activity with an ICofin HeLa cells. By repressing p300 histone acetyltransferase expression and reducing overall histone acetylation, FM19G11 impairs HIF-dependent transcriptional transactivation. Downstream inhibition of HIF-1α signaling decreases the expression of pluripotency factors such as Oct4 and Sox2, thereby impairing stem cell self-renewal and promoting cell differentiation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(200.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.