CAS No. 2226521-65-7
Batch:
Purity:99.30
Chemical Structure
Check the
FM-381
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide | |
|---|---|---|
| CAS Number | 2226521-65-7 | |
| Molecular Formula |
C24H24N6O2 |
|
| Molecular Weight (MW) | 428.49 | |
| SMILES | CN(C)C(=O)C(=CC1=CC=C(O1)C2=NC3=CN=C4C(=C3N2C5CCCCC5)C=CN4)C#N | |
| InChIKey | GJMZWYLOARVASY-NTCAYCPXSA-N |
FM-381 is a potent and selective reversible covalent inhibitor of JAK3 (IC50 127 pM), demonstrating 400-, 2,700-, and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively. By suppressing JAK3 kinase activity, FM-381 interrupts downstream STAT phosphorylation and dampens cytokine-mediated signaling pathways. This inhibition impairs lymphocyte proliferation and immune cell responses in inflammatory context models.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(46.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.