CAS No. 93957-54-1
Batch:
Purity:99.49
Chemical Structure
Check the
Fluvastatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid | |
|---|---|---|
| CAS Number | 93957-54-1 | |
| Molecular Formula |
C24H26FNO4 |
|
| Molecular Weight (MW) | 411.47 | |
| InChIKey | FJLGEFLZQAZZCD-JUFISIKESA-N |
Biological Activity
Fluvastatin is a competitive inhibitor of HMG-CoA reductase. By inhibiting HMG-CoA reductase, it blocks the rate-limiting step in mevalonate biosynthesis, thereby suppressing downstream cholesterol production. Additionally, fluvastatin exerts cytoprotective effects against oxidative stress by activating the Nrf2-dependent antioxidant pathway, leading to upregulated expression of cellular antioxidant enzymes and reduced reactive oxygen species accumulation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | 6 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.