CAS No. 397864-44-7

Batch: Purity:99.69
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fluticasone furoate Chemical Structure
Chemical Structure
Check the fluticasone furoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 397864-44-7
Molecular Formula

C27H29F3O6S
Molecular Weight (MW) 538.58
SMILES CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F

Ordering Information

Biological Activity

Fluticasone furoate is a synthetic fluorinated corticosteroid that acts as a potent glucocorticoid receptor agonist. Upon binding to the glucocorticoid receptor, it promotes receptor nuclear translocation and modulates gene transcription, thereby inhibiting NF-kB and AP-1 signaling pathways. Downstream, this action suppresses the expression of pro-inflammatory cytokines and chemokines, leading to reduced inflammatory cell recruitment and inhibition of mucosal inflammation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (185.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.