CAS No. 1841-19-6
Batch:
Purity:99.01
Chemical Structure
Check the
Fluspirilene
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | |
|---|---|---|
| CAS Number | 1841-19-6 | |
| Molecular Formula |
C29H31F2N3O |
|
| Molecular Weight (MW) | 475.57 | |
| InChIKey | QOYHHIBFXOOADH-UHFFFAOYSA-N |
Fluspirilene is a diphenylbutylpiperidine antipsychotic agent that acts as a potent non-competitive antagonist of voltage-gated L-type calcium channels. Blockade of these channels inhibits depolarization-induced transmembrane calcium influx and disrupts downstream intracellular calcium signaling pathways. This reduced intracellular calcium availability suppresses calcium-dependent excitation-contraction coupling and downstream cellular phenotypes, mediating its observed pharmacological effects. [1][2]
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.