CAS No. 146-56-5

Batch: Purity:99.27
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Fluphenazine dihydrochloride Chemical Structure
Chemical Structure
Check the Fluphenazine dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 146-56-5
Molecular Formula

C22H26F3N3OS.2HCl
Molecular Weight (MW) 510.44
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl

Biological Activity

Fluphenazine dihydrochloride is a phenothiazine-class antagonist of dopamine D1 and D2 receptors (D1DR and D2DR), as well as histamine H1 receptors. By blocking dopamine and histamine receptor signaling pathways, it modulates dopaminergic neurotransmission and downstream cyclic AMP (cAMP) accumulation. These actions disrupt receptor-mediated signaling cascades, leading to altered cellular signaling and neuroreceptor responses in central nervous system pathways. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (195.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 30 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kroeze WK, et al. Neuropsychopharmacology. 2003;28(3):519-26.

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Note: Technical data last updated: Sep 1, 2026.