CAS No. 426-13-1

Batch: Purity:99.99
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Fluorometholone Chemical Structure
Chemical Structure
Check the Fluorometholone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 426-13-1
Molecular Formula

C22H29FO4
Molecular Weight (MW) 376.46
SMILES CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O

Biological Activity

Fluorometholone is a synthetic glucocorticoid receptor agonist that exhibits anti-inflammatory and anti-allergic activities. Upon binding to the glucocorticoid receptor, it promotes receptor nuclear translocation and modulates gene transcription, resulting in the inhibition of pro-inflammatory pathways such as NF-kB signaling. This downstream signaling leads to the suppression of inflammatory mediators, leukocyte infiltration, and vascular permeability in target tissues.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.