CAS No. 3801-06-7

Batch: Purity:99.51
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Fluorometholone Acetate Chemical Structure
Chemical Structure
Check the Fluorometholone Acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3801-06-7
Molecular Formula

C24H31FO5
Molecular Weight (MW) 418.5
SMILES CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)OC(=O)C

Ordering Information

Biological Activity

Fluorometholone Acetate is a synthetic corticosteroid that acts as a potent glucocorticoid receptor agonist. Upon receptor binding, it modulates gene transcription to inhibit pro-inflammatory signaling cascades, notably suppressing NF-kB pathway activation. This transrepression suppresses the production of pro-inflammatory cytokines, chemokines, and inflammatory mediators, leading to reduced vascular permeability, decreased leukocyte infiltration, and attenuation of tissue swelling in ocular inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (198.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 83 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.