Fluorofenidone

For research use only.

Catalog No.E0084 Synonyms: AKF-PD

Fluorofenidone Chemical Structure

CAS No. 848353-85-5

Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway.

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Biological Activity

Description Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway.
Targets
NADPH-oxidase [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 41 mg/mL (201.76 mM)
Water Insoluble
Ethanol ''41 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 203.21
Formula

C12H10FNO

CAS No. 848353-85-5
Storage powder
in solvent
Synonyms AKF-PD

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID