CAS No. 514-36-3

Batch: Purity:99.6
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Fludrocortisone acetate Chemical Structure
Chemical Structure
Check the Fludrocortisone acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 514-36-3
Molecular Formula

C23H31FO6
Molecular Weight (MW) 422.49
SMILES CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O

Ordering Information

Biological Activity

Fludrocortisone acetate is a synthetic pregnane steroid that acts as a potent agonist of both mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Upon receptor binding, it drives target gene transcription, promoting renal sodium reabsorption, potassium excretion, and regulation of electrolyte and fluid balance. In cellular assays, activation of MR and GR pathways modulates downstream corticosteroid signaling and gene expression profiles. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (198.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 14 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.