CAS No. 2229050-90-0
Batch:
Purity:99.30
Chemical Structure
Check the
FLT3-IN-3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine | |
|---|---|---|
| CAS Number | 2229050-90-0 | |
| Molecular Formula |
C27H38N8O |
|
| Molecular Weight (MW) | 490.64 | |
| InChIKey | SAEGVASGMTZGFI-UHFFFAOYSA-N |
Biological Activity
FLT3-IN-3 is a potent FLT3 inhibitor targeting wild-type FLT3 as well as the FLT3 D835Y mutant. By suppressing FLT3 receptor tyrosine kinase activation, FLT3-IN-3 blocks downstream signaling pathways essential for leukemic survival and growth. Consequently, it effectively inhibits proliferation and suppresses cell viability in FLT3-ITD-positive acute myeloid leukemia models, including MV4-11 and MOLM-13 cell lines. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.