CAS No. 923562-23-6
Batch:
Purity:99.36
Chemical Structure
Check the
FLT3-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyridin-2-amine | |
|---|---|---|
| CAS Number | 923562-23-6 | |
| Molecular Formula |
C21H16ClF3N4 |
|
| Molecular Weight (MW) | 416.83 | |
| SMILES | FC(F)(F)C1=CC=C(CNC2=NC=C(CC3=C[NH]C4=NC=C(Cl)C=C34)C=C2)C=C1 | |
| InChIKey | MFXPJGJSKHZZGC-UHFFFAOYSA-N |
FLT3-IN-2 is a small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) with an IC50 of < 1 μM. By targeting FLT3, it disrupts autophosphorylation and downregulates downstream signaling pathways, including STAT5, AKT/mTOR, and MAPK/ERK. This inhibition suppresses cell proliferation and promotes apoptosis in acute myeloid leukemia cells, underlining the central role of FLT3 signaling in malignant hematopoiesis.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(47.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.