CAS No. 57415-44-8
Batch:
Purity:99.59
Chemical Structure
Check the
Flecainide hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;hydrochloride | |
|---|---|---|
| CAS Number | 57415-44-8 | |
| Molecular Formula |
C17H20F6N2O3.ClH |
|
| Molecular Weight (MW) | 450.80 | |
| InChIKey | FPTQDMHWQWTIAX-UHFFFAOYSA-N |
Flecainide hydrochloride is a class Ic antiarrhythmic agent that acts as a blocker of sodium channels. It also inhibits the ryanodine receptor 2 (RyR2), suppressing spontaneous sarcoplasmic reticulum calcium release in cardiomyocytes. By targeting both sodium channels and RyR2, flecainide regulates intracellular calcium dynamics and suppresses triggered activity to prevent ventricular arrhythmias. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.