CAS No. 135415-73-5
Batch:
Purity:99.00
Chemical Structure
Check the
FL118
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5S)-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaene-6,10-dione | |
|---|---|---|
| CAS Number | 135415-73-5 | |
| Molecular Formula |
C21H16N2O6 |
|
| Molecular Weight (MW) | 392.36 | |
| InChIKey | RPFYDENHBPRCTN-NRFANRHFSA-N |
FL118 is a camptothecin analog that acts as a potent inhibitor of Survivin while selectively and independently downregulating additional anti-apoptotic survival proteins, including Mcl-1, XIAP, and cIAP2, in a p53 status-independent manner. By suppressing these key inhibitor of apoptosis (IAP) and Bcl-2 family members, FL118 impairs anti-apoptotic survival signaling, thereby promoting cancer cell apoptosis and inhibiting tumor growth. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(10.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.