CAS No. 283167-06-6
Batch:
Purity:99.94
Chemical Structure
Check the
FK962
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(4-acetylcyclohexyl)-4-fluorobenzamide | |
|---|---|---|
| CAS Number | 283167-06-6 | |
| Molecular Formula |
C14H17FN2O2 |
|
| Molecular Weight (MW) | 264.3 | |
| SMILES | CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F | |
| InChIKey | PYMCWQVGVQEZNO-UHFFFAOYSA-N |
Biological Activity
FK962 is a candidate anti-dementia agent and derivative of FK960 that modulates somatostatin neurotransmission. It significantly enhances high K+-evoked somatostatin release from rat hippocampal slices at concentrations of 1–1000 nM. Furthermore, FK962 attenuates somatostatin-induced inhibition of Ca2+ channels at 1–100 nM in rat hippocampal neurons. Through these mechanisms, FK962 enhances somatostatinergic signaling and neuronal excitability, supporting its potential pro-cognitive activity.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(200.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 53 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.