CAS No. 1869057-83-9
Batch:
Purity:98.42
Chemical Structure
Check the
Firmonertinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1869057-83-9 | |
| Molecular Formula |
C28H31F3N8O2 |
|
| Molecular Weight (MW) | 568.59 | |
| InChIKey | GHKOONMJXNWOIW-UHFFFAOYSA-N |
Firmonertinib is an oral, brain-penetrant, mutant-selective inhibitor of EGFR targeting a broad spectrum of mutant forms, including exon 20 insertions and the T790M resistance mutation. By selectively inhibiting mutant EGFR autophosphorylation, it suppresses downstream AKT and MAPK signaling cascades. This pathway blockade leads to inhibited cell proliferation and survival in EGFR-mutant non-small cell lung cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(175.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.