CAS No. 869298-31-7

Batch: Purity:99.81
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FINO2 Chemical Structure
Chemical Structure
Check the FINO2 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl)ethanol
CAS Number 869298-31-7
Molecular Formula

C15H28O3
Molecular Weight (MW) 256.38
SMILES CC(C)(C)C1CCC2(CC1)CC(C)(CCO)OO2
InChIKey RWJLCLCUNHUSPG-UHFFFAOYSA-N

Ordering Information

Biological Activity

FINO2 is an endoperoxide-containing 1,2-dioxolane ferroptosis inducer that indirectly inhibits glutathione peroxidase 4 (GPX4) activity and directly oxidizes intracellular iron. By suppressing GPX4 enzymatic function without altering GPX4 protein expression, FINO2 promotes widespread lipid peroxidation and accumulation of lipid reactive oxygen species. These downstream metabolic disturbances disrupt cellular redox homeostasis, driving selective, non-apoptotic ferroptotic cell death in cancer cells. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (198.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 51 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.