CAS No. 2676211-64-4

Batch: Purity:97.13
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FHD-609 Chemical Structure
Chemical Structure
Check the FHD-609 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-3-[5-[7-[[1-[[4-[6-(azetidin-1-yl)-2-methyl-1-oxo-2,7-naphthyridin-4-yl]-2,6-dimethoxyphenyl]methyl]piperidin-4-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CAS Number 2676211-64-4
Molecular Formula

C47H56N8O6
Molecular Weight (MW) 829.00
InChIKey OBNRBCUHEAAFPS-KDXMTYKHSA-N

Biological Activity

FHD-609 acts as a selective inhibitor and heterobifunctional degrader of bromodomain-containing protein 9 (BRD9). By targeting the non-canonical BAF (ncBAF) chromatin remodeling complex, it promotes proteasomal degradation of BRD9, disrupting oncogenic gene expression programs. Consequently, BRD9 depletion suppresses cell proliferation and impairs tumor growth in models of synovial sarcoma and cancers associated with BAF complex subunit alterations.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (120.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Livingston JA, et al. Clin Cancer Res. 2025;31(4):628-638.

[2] Brien GL, et al. eLife. 2018;7:e41305.

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Note: Technical data last updated: Sep 1, 2026.