CAS No. 2671128-05-3

Batch: Purity:99.33
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FHD-286 (Camibirstat) Chemical Structure
Chemical Structure
Check the FHD-286 (Camibirstat) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(2S)-1-[[4-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-pyridinyl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
CAS Number 2671128-05-3
Molecular Formula

C24H30N6O6S2
Molecular Weight (MW) 562.66
SMILES COCC(NC(=O)C1=C[N](C=C1)[S;v6](C)(=O)=O)C(=O)NC2=NC(=CS2)C3=CC=CC(=N3)N4CC(C)OC(C)C4
InChIKey JBLQNFBXKOAIHG-FCEWJHQRSA-N

Ordering Information

Biological Activity

Camibirstat (FHD-286) is an orally bioavailable, allosteric dual inhibitor of the SWI/SNF (BAF) chromatin remodeling complex core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2). Selective inhibition of BRG1/BRM alters chromatin accessibility and represses downstream transcription factors including c-Myc and PU.1. This targeted disruption induces cell differentiation and reduces viability in acute myeloid leukemia stem cells, demonstrating potent preclinical antitumor activity in xenograft models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (177.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.