CAS No. 2308497-58-5
Batch:
Purity:99.44
Chemical Structure
Check the
FGFR1/DDR2 inhibitor 1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[3-(1-cyclopropylpyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide | |
|---|---|---|
| CAS Number | 2308497-58-5 | |
| Molecular Formula |
C28H22F3N5O |
|
| Molecular Weight (MW) | 501.5 | |
| InChIKey | ZEOWTGPWHLSLOG-UHFFFAOYSA-N |
FGFR1/DDR2 inhibitor 1 is a synthetic small-molecule kinase inhibitor targeting fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2). By blocking FGFR1 and DDR2 receptor tyrosine kinase activity, it disrupts downstream MAPK/ERK and PI3K/AKT signaling cascades. Consequently, inhibition of these pathways suppresses cell proliferation and promotes apoptosis in cancer cells dependent on FGFR1 or DDR2 signaling.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(199.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.